The idea that negative affective symptoms (in this case: depression) represent attempts to adapt to threat rather than evidence of a broken brain is independently and resoundingly supported by a large study of obese patients who explain why they regained their pathological levels immediately after reaching the goal weight!
https://www.huffingtonpost.com/entry/opinion-hari-depression-causes_us_5a6a144de4b0ddb658c46a21
This is why IRT therapists identify the perceived threat, associated affects and responses and their developmental origins as a part of the case formulation that subsequently directs the treatment.